Abstract 162

Objective: The aim of this study is to compare the analgesic effect of 25% sucrose and human milk in healthy term newborns. Study design: One hundred and two infants were randomly allocated to receive one of three solutions (sucrose, human milk, placebo) before the heel prick. The median values of crying time, recovery time and percentage change in heart rate at 1,2 and 3 mins were recorded. Results: Median crying times were 36, 52, and 62 sec in the sucrose, placebo and human milk groups, respectively (p=0.0009). In the sucrose group, there was a significant reduction in the crying time compared to human milk and placebo groups. The median recovery time in the sucrose group (72 sec) was shorter than that in the human milk (112 sec) and placebo groups (124 sec) (p=0.004). The percentage change in heart rate at 1,2 and 3 mins. were also found to be significantly lower in the sucrose group (p= 0.008, p= 0.01, p= 0.002 at the 1, 2, and 3 mins. respectively). Conclusion: It was concluded that the orosensorial antinociceptive effect of human milk is not as effective as an analgesic as a 25% sucrose solution.