Abstract 24
Animal's studies showed that intraperitoneal administration of vitamine E(E) decreases protein glucosilation (PG). "In vitro", E inhibits PG. E administration to diabetic adults reduce PG in relation to the dose received. E deficiency has been reported in diabetic patients without a good control of their disease. The glucosilated haemoglobine (HbA1c) percentage and its relationship with E nutritive state in type 1 diabetes are analyzed. METHODS: 119 children were analyzed subdivided into two groups homogeneous to age and sex. G-I (control), n:61, 9.5±0.5(mean±SEM) years old, M/F:33/28; and, G-II (insulin-dependent diabetes), n:58, 10.9±0.5 years old, M/F: 35/23, the length of disease was 4.7±0.6 years. Samples were taken in fasting between 8 and 10 o'clock in the morning. E (FABIANEK, 1968), total cholesterol, triglyceride and phospholipid plasma levels were measured by spectrophotometric method; E/total lipids (E/TL) ratio was evaluated. HbA1c by HPLC in erythrocites. RESULTS: The E/TL ratio (nutritional state of E) showed no differences between G-II and G-I: 2.3±0.1 vs 2.1±0.1 mg/g. HbA1c mean values were higher in G-II than in G-1: 8.9±0.3 vs 4.8±0.1%, p<0.001. Only in G-I a correlation between E levels and HbA1c percentage was observed (r:0.46, p<0.01). DISCUSSION & CONCLUSIONS: The positive effect of E to reduce HbA1c is obvious in physiological conditions. In those diabetic patients with HbA1c increased, antioxidant enzymatic activities could be inhibited. Glucose auto-oxidation generates H2O2. Free radicals are involved in PG pathogenesis. The present results suggest that "physiological levels of E in diabetic children are insufficient to soften HbA1c production".
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bayes, R., Campoy, C., Fernandez, J. et al. Relationships Between α-Tocopherol and Glucosilated Haemoglobin in Normal and in Type 1 Diabetes Affected Children. Pediatr Res 44, 423 (1998). https://doi.org/10.1203/00006450-199809000-00057
Issue Date:
DOI: https://doi.org/10.1203/00006450-199809000-00057
This article is cited by
-
Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus
European Journal of Clinical Nutrition (2002)