♦ Chemokines and Cytokines in Infection and Inflammation - Monday, May 4, 8:30 am - 10:00 am
Chair: Margaret K. Hostetter, University of Minnesota, Minneapolis
Response to infection or an inflammatory stimulus is dependent on the nature of the stimulus and a communications network between the cellular sensors of infection and cells of the inflammatory and immune response. Chemokines, cytokines and their receptors are key players in this network. The speakers in this symposium will address advances in our understanding of the initial cellular response to infection and the role of molecules which make up the signaling pathways between microbes, the cells they first contact and the effector cells of the immune response.
Craig Gerard, Children's Hospital, Boston
Chemokines and Viral Host Defense
Bruce Beutler, Howard Hughes Medical Institute, University of Texas Southwestern at Dallas
Genetics of Endotoxin Response
Martin Kagnoff, University of California San Diego
Epithelia cells sensors and signals for infection and inflammation
♦ Genes and Behavior - Sunday, May 3, 8:30 am - 10:30 am
Chair: Walter Miller, University of California, San Francisco
Sponsored in part by an educational grant from Pharmacia & Upjohn.
Recent advances in genetics and the biology of human development have suggested a role for inheritance in human behavior, personality traits and cognition. Understanding the molecular basis of these complex characteristics remains a major challenge. The speakers in this symposium will address advances in the study of genes regulating behavior from a clinical and basic perspective.
David Skuse, Institute of Child Health, University College, London, England
Imprinting, the X-chromosome and “The Male Brain”
Dean Hamer, National Cancer Institute
Genes for Human Personality and Behavior
Marc G. Caron, Duke University Medical Center
♦ Innate Immunity: The First Line of Defense - Saturday, May 2, 3:15 pm - 5:15 pm
Chair: Sam Hawgood, University of California San Francisco
Innate immunity refers to a means of pathogen recognition and defense that is based on a system of highly conserved pattern-recognition molecules that are not generally considered part of the acquired cellular or humoral system. In evolutionary terms the innate immune system is ancient but recent discoveries have highlighted the complexity and importance of this primitive system of host defense. The innate immune system remains the first line of host defense in humans, and may be of paramount importance before the acquired system has fully developed or when acquired immunity is disarmed by inherited defects or disease. Innate immunity may have the additional role of sorting self from non-self and determining which antigen the acquired immune system responds to. This session will review the scope of innate immune defenses highlighting the potential role of recently discovered serum and pulmonary surfactant proteins in protection from infection. Mechanisms of innate immunity may be of particular importance to the preterm neonate generally deficient in most aspects of acquired immunity.
Charles A. Janeway, Howard Hughes Medical Institute, Yale University School of Medicine
The Role of Innate Immunity in the Development of the Adaptive Immune Response
Alan B. Ezekowitz, Massachusetts General Hospital & Harvard Medical School
Pattern Recognition in Innate Immunity
Jo Rae Wright, Duke University Medical Center
Pulmonary Surfactant: A Front Line of Lung Host Defense
Rights and permissions
About this article
Cite this article
Topic Symposia. Pediatr Res 43 (Suppl 4), 23 (1998). https://doi.org/10.1203/00006450-199804001-00010
Issue Date:
DOI: https://doi.org/10.1203/00006450-199804001-00010