Several hormones participate in Gastrointestinal tract development. Small volumes of enteral feedings only to stimulate the release of these grastrointestinal hormones is known as Enteral Stimulation.Objective To evaluate the effect of Early Enteral Stimulation (EES) on gastric tolerance and weight gain during the first month of life in Very Low Birth Weight Infants (VLBW). Subjects: Adequate for Gestational Age (AGA) or Small for Gestational Age (SGA) Neonates less than 1500 g with or without associated disease according to previous definition. Major congenital malformations, inborn errors of metabolism and imminent risk of death were excluded. EES: Administration of a constant volume=25ml kg/day of breast milk(BM) or premature formula (F). Patients were divided in 2 groups: AGA and SGA and then subdivided in healthy or sick. These 4 subgroups are randomized to receive EES or Standard Care (NPO). EES is started at 12 to 24 hours of life in healthy neonates and at 36 to 48 hours of life in sick neonates. EES is kept for 48 hours in healthy and for 6 to 8 days in sick neonates. Then EES and Standard Care group are then fed with similar increments of BM or F. Information on Maternal drugs, Perinatal Diseases, Post-Natal Complications, Feeding Tolerance and Nutrition was recorded. Results: the goal is to recruit 400 patients in 2 years. At present, Standard group has been similar (1176/1137). The% of sick and healthy AGA and SGA are similar in both groups. There has been no significant difference in the number of days to recover birth weight (16.03/16.15), days to reach 2000 grams (44.7/46.5) and days with I.V. fluids (15.2/14.4) when data is analized without dividing in healthy and sick subgroups. The number of patients with Necrotizing Enterololitis has bee the same in both groups (5). Comments: These are preliminary results, there has been neither positive effects, nor more complications associated to EES. Further conclusions must wait for a greater number of patients.