Aim: To establish prevalence of antenatally acquired haemorrhagic-ischaemic (HI) lesions among preterm infants < 34 wks GA and to compare their antenatal and obstetrical risk factors with those of infants with similar lesions of postnatal onset.
Subjects: 1234 infants were studied prospectively, using serial cranial US. The entry criteria for antenatal onset (Group A) were: a) extensive cysts (n=7) or b) a porencephalic cyst < 3 d (n=1); c) pre-cystic lesions confirmed to be white matter damage at autopsy (n=4), d) symmetric thalamic lesions (n=2) and e) subependymal pseudocysts (n=14). Group B were those with an initial normal US with subsequent development of a-d type of lesions. Results: Only 35 (2.9%) met the entry criteria for group A and 83 for group B. On comparison of obstetrical risk factors between these two groups a significant difference for GA was found (31.3 versus 28.8; p=0.0003). Significant more abnormal CTGs were found in group A (p=0.006), also after logistic regression analysis and significant more PROM was found in group B (p=0.02).
Conclusion: Antenatal onset of HI lesions is not common in preterm infants. CTGs can be abnormal, often leading to emergency CS, in infants with well established brain lesions.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
de Vries, L., Groenendaal, F., Rademaker, K. et al. Antenatal Onset of Haemorrhagic-Ischaemic Lesions in Preterm Infants 243. Pediatr Res 40, 555 (1996). https://doi.org/10.1203/00006450-199609000-00266
Issue Date:
DOI: https://doi.org/10.1203/00006450-199609000-00266