Background: Bolus administration of surfactant (surf) can lead to obstruction of bronchus or endotracheal tube and has potential hazards concerning circulation and cerebral perfusion. We gave surf as a slow infusion (inf) via a small catheter within the tube and compared effects on static compliance (C) and resistance(R) with the recommended bolus administration (bol).
Subjects: 18 infants with RDS (27-39 weeks GA: 0.7-3.3 kg BW; FiO2 0.3-1.0)
Interventions: 15 infants randomized for either inf or bol with bovine surf (18 interventions), 3 controls(con) treated with synthetic surf as fractionated bol. Measurement of C every 3 min.
Results: Given as mean of Ctn/Cto or Rtn/Rto± S.D. (tn = time 15/45/75 min; to = start of treatment). Difference of inf vs. bol not significant for p <.05 at each tn. Table
Conclusions: Natural surf leads to increase of R, whereas C first decreases and then increases. Course of C or R is not different in both treatments. Synthetic surf has no effect on C or R.
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(Supported by German Research Council (DFG) # He 1835/1-1)
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Hentschel, R., Brune, T., Rabe, H. et al. Effects on Compliance and Resistance of Bolus Administration vs. Slow Infusion of Surfactant 113. Pediatr Res 40, 534 (1996). https://doi.org/10.1203/00006450-199609000-00136
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DOI: https://doi.org/10.1203/00006450-199609000-00136
