Background: In using magneting resonance (MR) technique for the investigation of preterm infants, several safety and environmental precautions must be met.

Material and Methods: We constructed a MR compatible incubator and modified the imaging sequences. The incubator is designed as large as possible to fit the bore of the magnet, has a computer regulated temperature/air flow. Conventional MR devices are used for monitoring of vital signs. A TV camera with a wide angle lens is mounted to permit visual control of the infant. “Quiet” sequences were designed to reduce the high noise level during examinations.

Results: The temperature variation at the center of the incubator was measured to less than +/- 0.4 °C/hour. The noise reduction measured 3 m from the center of the magnet was 20 dB. Two infants needing nasal CPAP and one on mechanical ventilation have been successfully examined using the device.

Conclusions: Early examinations of newborn infants with MR imaging, spectroscopy and functional MR are possible at a postnatal age when ongoing pathophysiological sequences are still likely. This will advance our knowledge on the evolution of pathologies like periventricular leukomalacia. The “quiet” sequences will permit functional examinations of the un-sedated newborn infant.