234 toddlers were equally randomized to receive one dose of Takeda acellular pertussis vaccine combined with D and T either simultaneously with HbOC (DTaP + HbOC) or combined in the same syringe (DTaP/HbOC; TETRACEL™). Enrollment was stratified into 2 age groups: 12 to < 15 mo. and ≥ 15 mo. to 18 mo. IgG antibody to PRP, measured by standardized EIA methods on pre and 1 mo. post-vaccination bloods are shown below:Table
Anti-PRP responses were comparable following combined and concurrent vaccination.
Post vaccination GMTs were higher among the older children, but the differences were not significant. DTaP/HbOC was highly immunogenic in both age groups.
We conclude that DTaP/HbOC is effective as a booster in children aged 12 - 18 mo.
(Spon. by Christopher N. Frantz).The study was sponsored by Wyeth-Lederle Vaccines and Pediatrics.
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Rennels, M., Clements, D., Reisinger, K. et al. ANTI-PRP RESPONSES INDUCED BY DTaP AND HbOC ADMINISTERED CONCURRENTLY VERSUS COMBINED IN CHILDREN < 15 MONTHS VERSUS ≥ 15 MONTHS. ▴ 1081. Pediatr Res 39, 183 (1996). https://doi.org/10.1203/00006450-199604001-01103