Abstract
We studied the influence of therapy with cortisone acetate (CO) 20 mg/m2/day and 9a fluorohydrocortiscne (9F) 50 μg/day, on BMD of lumbar spine L2-L4 by dual energy x-ray absorptiometry (Kologic QDR-1000) in 17 patients with CAH (4 salt wasting and 13 with simple virilizing forms). BMD was expressed as % of the value observed in normal children of same chronological age (CA) and race. Due to the advancement of height age (HA) and bone age (BA) in some patients with CAH, BMD was also compared with these ages. Duration of therapy ranged from 0.7 to 9.8 years, with a mean of 4.7 years. Patients were divided into 3 groups: G1 on treatment with CO and 9F and good hormonal control, G2 on treatment with CO and 9F with fair hormonal control, and G3 with CO only and fair hormonal control.
BMD was normal when compared to CA, HA and BA in all types of therapy and hormonal control. We observed an inverse correlation between the years of advancement in BA (BA-CA) and BMD % for 3A (p=0.009), suggesting that BMD does not follow bone maturation. We conclude that patients with CAH treated with CO alone or with 9F have normal BMD.
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Bachega, T., Madureira, G., Matielli, J. et al. BONE MINERAL DENSITY (BMD) DURING THERAPY FOR CONGENITAL ADRENAL KYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY (CAH). Pediatr Res 38, 623 (1995). https://doi.org/10.1203/00006450-199510000-00038
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DOI: https://doi.org/10.1203/00006450-199510000-00038