Progressive Normalization of Growth Hormone-Binding Protein and IGF-I Levels in Treated Growth Hormone-Deficient Children

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ABSTRACT: The short- and long-term effects of hGH treatment on growth hormone (GH)-binding protein (GHBP) were examined in 18 prepubertal children, aged 1.5–10 y, with isolated idiopathic GH deficiency. The patients were studied before and at regular intervals during 24 mo of hGH therapy (0.6 IU/kg/wk, given daily). Pretreatment GHBP values were low: 14.6 ± 1.2% of radioactivity (p < 0.0001 versus normal prepubertal children). After the first hGH injection, GHBP levels fell significantly at 6 h (8.2 ± 1.3% of radioactivity) and then remained at basal level during the first week. Under hGH therapy, an increase in GHBP was observed, but it occurred at different times of treatment, from 1 to 12 mo, and the mean GHBP value became significantly higher than the value before treatment after 12 mo of therapy. An increase in serum IGF-1 level was observed as soon as 1 wk of hGH therapy, and after 3 mo, the mean IGF-I value was normal. No correlation was found between the increase in GHBP, IGF-I levels, and the growth velocity at 12 and 24 mo of treatment. These findings support the role of GH in the regulation of GHBP/receptor in main. The time course of the GH effect appears to be progressive and variable.

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Correspondence to Marie-Catherine Postel-Vinay.

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Leger, J., Noel, M., Czernichow, P. et al. Progressive Normalization of Growth Hormone-Binding Protein and IGF-I Levels in Treated Growth Hormone-Deficient Children. Pediatr Res 37, 731–735 (1995). https://doi.org/10.1203/00006450-199506000-00010

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