Abstract
Interferences of copper (Cu) and molybdenum (Mo) metabolism have been described (1). We evaluated in preterm infants 1.Cu balances under consideration of formula Mo content and 2. the course of the Cu concentration in feces and urine in stable isotope studies with 100Mo.
1.) Intake, urinary and fecal excretion were collected over 72 hrs. in 14 male infants (gest. age: 32-37, 1.5-2.0 kg birth weight, 22 balances, formula: Prematil (Milupa AG, Germany)); Mo and Cu concentrations were determined by atomic absorption spectrometry :
2.) In 10 preterm infants fecal and urinary specimens were collected over 48-72 hrs. after the intake of 25 μg/kg 100Mo added to formula. Within 14 hours urinary Mo increased 13(4-84)fold. For fecal Mo a 3.2(1.1-5.5)fold increase was observed in all but 2 infants within 24(6-26.25)hrs. Compared to the initial values, in 6/9 infants Cu concentrations increased up to 220(183-326)% in urine and 142(120-156)% in feces after the 100Mo intake. In the others, specimens preceeding the 100Mo intake rendered the highest Cu concentrations. Despite their considerable range the results suggest a potential influence of Mo intake on Cu excretion. (1)AmJClinNutr(1972); 25:1022-1037.
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Sievers, E., Dörner, K., Oldigs, HD. et al. 210 COPPER/MOLYBDENUM METABOLISM – INTERRELATIONSHIP IN PRETERM INFANTS?. Pediatr Res 36, 37 (1994). https://doi.org/10.1203/00006450-199407000-00210
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DOI: https://doi.org/10.1203/00006450-199407000-00210