Abstract
Hypothesis: Urogenital Mycoplasmas are associated with the Development of Chronic Lung Disease in the immature infant.
Study Type: Prospective cohort study in a tertiary neonatal service
Patients: 63 consecutive intubated newborn infants less than 30 weeks gestation.
Measurements: The endotracheal secretions of all intubated neonates (n = 63) were examined weekly over a nine month period for all common bacterial pathogens..
Results: 25% (16) of the infants yielded positive for U urealyticum and/or M hominis. Positive culture was obtained on the first specimen in 69% (11) but in 31 % (5) positive culture was only obtained on the second or subsequent specimen. CLD occurred in 38% (18) of the culture negative group, and in 94% (15) of the culture positive group (p< 0.001). Of infants who were culture positive on the first specimen 81 % (9/11) developed CLD of those positive on the second or subsequent specimen, 83% (5/6) developed CLD. There were no significant differences between the groups for gestation, birthweight, or time ventilated.
Conclusion: This data suggests that U urealyticum and M hominis are of aetiologic significance in the development of CLD. An intervention study has been started looking at the relationship between infection, acute inflammatory response and CLD and the effect of early treatment with erythromycin.
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Lies, R., Lyon, A., Ross, P. et al. 100 Urogenital Mycoplasmas in Neonatal Endotracheal Secretions and the Development of Chronic Lung Disease (CLD). Pediatr Res 36, 19 (1994). https://doi.org/10.1203/00006450-199407000-00100
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DOI: https://doi.org/10.1203/00006450-199407000-00100