Abstract
Surfactant deficiency was induced in seven newborn pigs (3-5 days of age) by repetitive lung lavage. Natural porcine surfactant was instilled into the lungs, intratissue Po2 was measured continuously polarographically with a needle oxygen electrode in the medial muscle of one thigh and compared with arterial PaO2. Intratissue Po2 [was initially 3.2±0.5 kPa (mean±SCH and fell to 1.5±0.7 kPa at the end Of lung wash. 2.5 minutes after surfactant was instilled intratissue Po2 started to increase reaching a maximum of 3.5±0.6 kPa after 20 min. There was a highly linear correlation between arterial and intratissue Po2 (r=0.95,p<0.001, n=71).
Conclusion: Intratissue Po2 fluctuates in parallel with arterial PaO2 and is highly correlated with this. Replacement therapy with natural porcine surfactant in surfactant depleted newborn pigs quickly restores intratissue Po2
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Hornakova, A., Curstedt, T., Robertson, B. et al. 99 VARIATION IN INTRATISSUE Po2 IN RELATION TO SURFACTANT REPLACEMENT IN SURFACTANT DEPLETED NEWBORN PIGS. Pediatr Res 36, 19 (1994). https://doi.org/10.1203/00006450-199407000-00099
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DOI: https://doi.org/10.1203/00006450-199407000-00099