Abstract
Newborn infants have an increased susceptibility to serious infections. Neutrophil granulocytes play an important role in the defence against infections. We have studied the expression of the receptors for phagocytosis and adhesion (CD11 b, CD16, CD18, CD32, CD35 and Leu8) on neutrophil granulocytes from newborn infants and compared with results found in adults.
Subjects and methods: Blood samples were taken from 18 term newborn infants (cord; blood) and 30 healthy adults. The granulocytes were fixed with formaldehyde and incubated with monoclonal antibodies against each receptor. The cells were then analyzed by flow cytometry (Epics Profil II).
Results: For CD11b, CD16, CD18, CD32, and Leu8, there was no significant difference in receptor expression between granulocytes from newborns and those from adults. There was a trend towards increased expression of the CD35 receptor (p=O,068), and the expression of CD16 was significantly decreased (p=0,046) on granulocytes from newborns.
Conclusion: With exception for a tendency of an increased expression of the complement receptor CD35 and a decreased expression of the Fc-receptor CD16, no significant differences were found between newborn infants and adults.
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Fjaertoft, G., Ewald, U., Foucard, T. et al. 65 RECEPTORS FOR PHAGOCYTOSIS AND ADHESION ON NEUTROPHIL GRANULOCYTES IN NEWBORN INFANTS. Pediatr Res 36, 13 (1994). https://doi.org/10.1203/00006450-199407000-00065
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DOI: https://doi.org/10.1203/00006450-199407000-00065