Abstract
ABSTRACT: Adipocyte plasma membranes were isolated from four patients with type la pseudohypoparathyroidism, a disease in which deficiency of the stimulatory guanine nucleotide binding protein Gs has been reported, and from controls. Stimulation of adenylate cyclase by isoproterenol was defective, whereas inhibition of forskolin-stimulated cyclase activity by N6-(phenylisopropyl)adenosine was normal. The patients had low serum FFA concentrations and developed obesity in childhood. These results suggest that pseudohypoparathyroidism 1a is connected with a blunted stimulatory response of adenylate cyclase, possibly because of low Gs activity, and that this blunted response may lead to decreased lipolysis and to obesity.
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Kaartinen, J., Käär, ML. & Ohisalo, J. Defective Stimulation of Adipocyte Adenylate Cyclase, Blunted Lipolysis, and Obesity in Pseudohypoparathyroidism 1a. Pediatr Res 35, 594–597 (1994). https://doi.org/10.1203/00006450-199405000-00011
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DOI: https://doi.org/10.1203/00006450-199405000-00011
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