Abstract
Indomethacine (Indo) is commonly used for treatment of PDA, its main side effect is renal failure. Aspirin (ASA) is an alternative but there are no controlled trials on its efficacy. We randomly assigned 75 premature infants suffering from RDS (mean GA: 29.6 ± 2.5 wks, mean BW: 1295 ± 464 gr) on artificial ventilation at start of study (mean : 3.4 day of life), to either Indo (3 × 0.2 mg/kg/12 hrs) or ASA (4 × 15 mg/kg/6 hrs). PDA and degree of shunting were diagnosed by echocardio-Doppler at start and after 2 and 4 days. Side effects, especially diminution of diuresis, were carefully recorded.
Results: PDA closed in 35/38 patients from the Indo group (93 %) and in 16/37 patients from the ASA group (43 %) (p<0.001). No reopenings were observed in both groups. 19 patients needed further treatment with Indo or surgery (17 in the ASA group and 2 in the Indo group). No side effects ware seen in both groups except for a decrease of diuresis in the Indogroup during 4 posttreatment days (difference on 2nd posttreatment day: Indo minus 1.06 ml/kg/h vs ASA: plus 0.48 ml/kg/h; p<0.01). Fluid management was not different between both groups. Closing of PDA was positively correlated with CA, but not with time of starting Indo/ASA or grade of shunting.
Conciusion:ASA is not as effective in closing PDA as Indo, but has no adverse effect on diuresis.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Overmeire, B., Brus, F., Elzenga, N. et al. ASPIRIN VERSUS INDOMETHACINE TREATMENT OF PATENT DUCTUS ARTERIOSUS (PDA) IN THE PRETERM NEONATE WITH RESPIRATORY DISTRESS SYNDROME (RDS). Pediatr Res 35, 279 (1994). https://doi.org/10.1203/00006450-199402000-00149
Issue Date:
DOI: https://doi.org/10.1203/00006450-199402000-00149