Abstract
SI occurs during several clinical disorders and primarely affects the lung. To determine wether SI exists in IRDS we measured activation of clotting (thrombin-antithrombin III complex,T-AT III), fibrinolysis (tissue plasminogen activator, t-PA; fibrin degeneration products, FDP's), kinin-kallikrein (kallikrein inhibition, KKI), and complement (C3a) and the leukocyte and platelet count in 10 premature infants with severe IRDS on day 1, 3, and 5 (sec table).
We conclude that SI including a low leukocyte and platelet count and activation of clotting, fibrinolysis and complement occurs in premature infants during the early phase of severe IRDS. This likely contributes to lung injury.
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Brus, F., Van Oeveren, W., Oetomo, S. et al. SYSTEMIC INFLAMMATION (SI) IN THE SEVERE IDIOPATHIC RESPIRATORY DISTRESS SYNDROME (IRDS). Pediatr Res 35, 270 (1994). https://doi.org/10.1203/00006450-199402000-00096
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DOI: https://doi.org/10.1203/00006450-199402000-00096