Abstract
In our ongoing studies, 60 girls with CPP have been evaluated at 6-12m intervals for ≥ 12 months following the discontinuation of GnRHa. All received daily sc injections of either deslorelin or histrelin for 3.8 ± 0.2 years (range 2.0-7.7). Of these 60 girls, 36 have attained their final height (at FHT; GV < 2 cm/year, TW BA = 16 years), while the remainder have some residual growth potential (near FHT). In both subsets, the latest measured HT, while remaining 7.1 ± 1.0 cm below the genetic target HT, significantly exceeded the Bayley-Pinneau prediction prior to GnRHa administration (*, p = 0.0001). A single girl with a pre-GnRHa BA < 10 yrs has reached her FHT, while such patients comprise 34% of our total CPP female population. Since changes in predicted HT during GnRHa administration correlate significantly with pretherapy CA and BA, we must still await the FHT outcomes in young patients enrolled early in puberty to judge comprehensively the impact of gonadal sex steroid suppression on FHT in patients with CPP.
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Boepple, P., Mansfield, M., Crawford, J. et al. FINAL HEIGHTS FOLLOWING GnRHa-INDUCED PITUITARY-CONADAL SUPPRESSION IN GIRLS WITH CENTRAL PRECOCIOUS PUBERTY (CPP). Pediatr Res 33 (Suppl 5), S88 (1993). https://doi.org/10.1203/00006450-199305001-00510
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DOI: https://doi.org/10.1203/00006450-199305001-00510