Abstract
To investigate whether GnRH and TRH test during prepubertal period is useful for the diagnosis of gonadotropin deficiency in short children, 20 children (12 boys, 15.7±0.6 years old and 8 girls, 17.9±1.0 years old) were evaluated. All have received GH replacement according to the Japanese standard of assessment of short stature. Seven {4 boys and 3 girls} of the 20 children have multiple pituitary hormone deficiencies (MPHD) without the occurrence of puberty, who had been treated with thyroxine, cortisol and so on. Other 13 (8 boys and 5 girls) presumed to be isolated GH deficiency (IGHD) show normal pubertal development. The levels of LH, FSH and prolactin (PRL) on GnRH (2μg/kg) and TRH 10μg/kg) test during prepubertal period were compared between the MPHD and the IGHD. The chronological age when the tests were performed was at 9.8±0.9 years old in both groups. In boys, ΔFSH levels were decreased and basal PRL levels were increased in the MPHD as compared with those of the IGHD (0.9±0.4 vs 10.7±1.9 mIU/ml, 24.7±4.2 vs 12.5±2.5 ng/ml, respectively). In girls, basal LH and FSH, peak FSH and ΔFSH were decreased and basal PRL levels were increased in the MPHD as compared with those of the IGHD (3.6±0.9 vs 1.0±0.4 mIU/ml, 2.0±0.0 ve 3.8±0.3 mIU/ml, 5.2±2.5 vs 19.5±2.8 mIU/ml, 3.2±6.1 vs 15.7±2.5 mIU/ml, 19.0±3.0 vs 3.5±1.4 ng/ml, respectively). These results suggest that the subnormal response of gonadotropins to GnRH and the increased level of basal PRL might be an available index for the prediction of the absence of puberty in short children at adolescent age.
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Yamamoto, T., Nukina, S., Matsuo, S. et al. CAN GNRH AND TRH TEST DURING PREPUBERTAL PERIOD PREDICT THE OCCURRENCE OF PUBERTY IN SHORT CHILDREN?. Pediatr Res 33 (Suppl 5), S87 (1993). https://doi.org/10.1203/00006450-199305001-00504
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DOI: https://doi.org/10.1203/00006450-199305001-00504