Abstract
The effects of prophylactic administration of 400 IU containing vitamin D3 tablets were tested in 2707 newborn to 15-month-old infants. Only Vitamin D free formula milks were used in formula-fed infants. Vitamin D3 prophylaxis was started in the 2nd week of life. 57 out of 89 (64%1) one-week- old newborns had 25 OH-D serum conc. below 201 nmol/l (range 20-130 nmol/l, method Aksnes et al. Clin. Chem. Acta 104, 1980:133, 147). Under 400 IU of vit.D3/day 25 OH-D increased from 22.6 ± 13.8 to 83.1 ± 36.1 nmol/l from the 2nd week to the 3rd month (n = 163, p < 0.0001) and to 93.9 ± 36.6 nmol/l between 4-6 months (n = 182, p > 0.0001). Elevated 25 OH-D conc. (>130 nmol/l) were found in 35/315 (10.1%) in the first half year and 4/149 (2.6%) in the second one. Elevated calcium serum conc. (> 2.8 mmol/l) were observed in 28 of 439. infants (6.4 %) in the first 6 months. Anorg. phosphate conc. above > 2.4 mmol/l were measured in 143 of 616 (23.2 %). (Ca values < 2.0 mmol/l = 2). One of 2707 infants had rickets. Slightly elevated alk. phosph. conc. (> 12.5 umol/l.s were found in 87 of 676 infants (12.9 %) in spite of normal Ca, P and 25 OH-D conc.
Concl.: Daily applic. of 400 IE Vit.D3 day leads to increased 25 OH-D and calc. conc. in the first 6 months of life. 300 IE vit. D3/day are recommended as prophylactic dose for the first and 400 IE/day for the second half year of life.
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Hesse, V., Kapuhs, A., Badecke, E. et al. LOW DOSES UF VITAMIN D3 ARE TO REQUIRE FOR RICKETS PROPHYLAXIS. Pediatr Res 33 (Suppl 5), S81 (1993). https://doi.org/10.1203/00006450-199305001-00468
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DOI: https://doi.org/10.1203/00006450-199305001-00468