Abstract
To evaluate side effects of a human growth hormone therapy (r-hGH) we performed standard ECG-gated MRI (multiple slice echo sequence, 1.5 T). We investigated 12 girls with Turner's syndrome (TS, chronological age 3.5 to 19.1 years, r-hGH dosis 13-24 IU/m2/Week, period of treatment 24 to 35 months) and 14 children (normotonic) with chronic renal failure (CRF, chron. age 4.1 to 15.6 years, r-hGH dosis 23-32 IU/m2/w, treatment period 3 to 11 months). There were no pathological findings in the group of TS patients whereas in 3 of 14 cases suffering from CRF we have seen circumscriptal thickness of the central and basal part of the septum of the heart without any evidence of left ventricular hypertrophy. The signal intensity of these suspected areas were identical to normal myocardium. These abnormalities were found to be unchanged (e.g. without any progression) under further treatment of 6 months. Although the etiology of this regional myocardial hypertrophy of the intraventricular septum of the heart is still unknown, such myocardial changes may be related to metabolic disturbances in uremic children and/or to the higher r-hGH dosis used in tne group of CSF in comparison to TS.
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Amendt, P., Sandring, K. & Gellert, S. CARDIAC MRI IN R-HGH TREATED CHILDREN. Pediatr Res 33 (Suppl 5), S61 (1993). https://doi.org/10.1203/00006450-199305001-00350
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DOI: https://doi.org/10.1203/00006450-199305001-00350