Abstract
Urinary HGH has been proposed to evaluate HGH secretion. Renal excretion of microproteins, including HGH, depend on GFR and proximal tubular reabsorption. In 15 children with various renal diseases HGH excretion was compared to inulin clearance (GFR) with a mean±SEM of 108115 ml/min*1.73m2 (range 22-238) and renal tubular function determined by albumin (ALB) and α1-microglobulin (α1-MG) excretion under standardized conditions (fasting, volume load 2% of body weight per h). HGH concentrations (n=44) were measured with two different antibodies by RIA, Nordisk and own (Girard) method. With both assays HGH was significantly correlated to ALB (mean±SEM: 628±342mg/l) with R of 0,50 (p<0.001, Nordisk) and R=0,41 (p<0.01, Girard), and α1-MG (7.9±3.0 mg/l) with R=0,42 and R=0,52 (p<0.01 and p<0.001). FE of HGH was inversely correlated to GFR (R=0.61, p<0.001) but independent of urinary flow rate.
Conclusion: To exclude disturbed renal handling urinary HGH concentrations should be evaluated in conjunction with albumin and α1-MG to establish glomerular and proximal tubular integrity.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zimmerhackl, L., Petrykowski, W., Hentschel, M. et al. RENAL FRACTIONAL EXCRETION (FE) OF HUMAN GROWTH HORMONE (HGH) IS CORRELATED TO INULIN CLEARANCE (GFR) AND PROXIMAL TUBULAR FUNCTION. Pediatr Res 33 (Suppl 5), S61 (1993). https://doi.org/10.1203/00006450-199305001-00345
Issue Date:
DOI: https://doi.org/10.1203/00006450-199305001-00345