Abstract
Five patients with mixed dysgenesis (karyotype XO/XY) were treated with biosynthetic growth hormone (GH) for two years. Three patients (1, 2 and 3) presented with ambiguous genitalia at birth and after treatment were reared as girls. The other two (4 and 5) were reared as males, Standard GH-stimulationtests, as well as 24 h. GH profiles performed prior to treatment were in the normal range. GH dosis used was 24 U/m2/week S.C. given in 6 daily doses.
It is concluded that in XO/XY karyotype, treatment with GH in a dose of 24 u/m2/ week results in a significant increase in growth velocity in the first 2 years of treatment and in an increase in height prediction.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Otten, B., Rongen-Westerlaken, C. & Velden, B. TREATMENT OF PATIENTS WITH MIXED GONADAL DYSGENESIS (KARYOTYPE XO/XY) WITH BIOSYNTHETIC GROWTH HORMONE 24 U/m/WEEK RESULTS IN INCREASED GROWTH VELOCITY: TWO YEAR RESULTS. Pediatr Res 33 (Suppl 5), S59 (1993). https://doi.org/10.1203/00006450-199305001-00337
Issue Date:
DOI: https://doi.org/10.1203/00006450-199305001-00337