Abstract
Serum IgA gluten antibody levels (ELISA method) were measured in 83 children (53 boys and 30 girls - 11.1 ± 3.4 years of age) under growth hormone (GH) therapy (24.4 ± 4.1 months duration) for short stature (−2.87 ± 1.15 SD) due to GH deficiency (peak GH < 10 ng/ml at 2 provocative tests) as well as prospectively in 147 children (110 boys and 37 girls - 11.2 ± 3.3 years of age) without abdominal symtoms, normal body mass index (16.7 ± 2.3) and normal endoucrinological evaluation referred to the outpatient clinic for short stature (−2.12 ± 0.83 SD). Elevated (≥ 30 uniis) gluten IgA antibody levels were detected in 8 children (2 GH-deficient and 6 non GH-deficient). Three of them (1 GH-D and 2 non GH-D had probable coeliac disease based on villus atrophy at duodenal biopsy. Intestinal permeability assessed by excretion ratio of Lactulose and Mannitol was altered in these 3 patients. Three girls (I GH-D and 2 non GH-D) with highly positive IGA antibodies had a normal duodenal biopsy. It is concluded that measurement of gluten antibodies, especially of the IgA type, should be included in the diagnostic evaluation of children with short stature as well as in the reevaluation of GH-treated children for GH deficiency. Howevcr, positive IgA gluten antibodies may be found in patients wiih normal intestinal nuccosa.
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Colle, M., Lamireau, T., Appriou, M. et al. SCREENING FOR COELIAC DISEASE BY DETERMINATION OF IGA GLIADIN ANTIBODIES IN CHILDREN WITH GROWTH-HORMONE DEFICIENCY AND IN CHILDREN OF SHORT STATURE. Pediatr Res 33 (Suppl 5), S59 (1993). https://doi.org/10.1203/00006450-199305001-00333
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DOI: https://doi.org/10.1203/00006450-199305001-00333