Abstract
The serum half-life of the glycosylated GH-BP in the human is currently unknown. Circulating levels of the high affinity GH-BP are low in the neonatal period compared to adult life (Massa et al, Pediatr Res 1992). During an exchange transfusion (ET) for neonatal hyperbilirubinemia, the blood of the newborn is nearly completely replaced by adult donor blood. To evaluate the elimination rate of GH-BP we measured serum levels of GH-BP by HPLC gel filtration before and at different time intervals after an ET in 4 term neonates. Before the ET the mean±SE serum binding of 125I-hGH (GH-BP) was 6.7±1.2%. At the end of the ET, serum GH-BP was increased to 25.3±2.6% (P<0.005). Thereafter serum GH-BP decreased slowly and was 84 to 96 hours later still higher than before the ET. Analysis of the elimination curve by exponential stripping suggested an elimination according to a bi-exponential model : GH-BP(%) = 40 × e(5.1 x-03 ×time) + 64 x e(−2.5x-04 × time). The seruin half-life of the GH-BP complex was estimated to be 1.9 days. These data demonstrate : 1) that the GH-BP can be transfused, and 2) that the serum half-life of the GH-BP complex in neonates is in the order of magnitude of days. (This work was supported by a grant from the Belgian study Group of Pediatric Endocrinology).
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Massa, G., de Zegher, F. & Vanderschueren-Lodeweyckx, M. SERUM HALF-LIFE OF GROWTH HORMONE-BINDING PROTEIN (GH-BP) ASSESSED IN THE HUMAN NEWBORN. Pediatr Res 33 (Suppl 5), S56 (1993). https://doi.org/10.1203/00006450-199305001-00317
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DOI: https://doi.org/10.1203/00006450-199305001-00317