Abstract
Seventy three peripubertal children (49 M, 24F) were studied. Height was <2 SD for age and gender, growth velocity was <4.5 cm/year, bone age was more than 2 SD below mean for age and GH response to provocative tests (PT) was <10 mcg/L in 12 children (group GHD). PT was >10 mcg/L in 61 children of which 31 subjects (group T) were treated with GH 0.75 u/kg/week for 2-5 years, until FH was attained. 20 (group C) were untreated children who were followed until cessation of growth and served as controls. The Tanner-whitehouse (TW) and the Bayley-Pinneau (BP) predictions (in SDS) were highly correlated with FH in treated groups (r=0.747 and r=0.646, p<0.02). The TW and BP methods over estimated FH in treated groups by 3.6 and 3 cm. The untreated group was shorter by 0.7 EDS than the treated groups. Neither protreatment height velocity nor GH measurements by physiologic or pharmacologic tests were correlated with FH. The main effect of GH was observed during the first year of treatment in group T when height velocity was significantly higher in the than in the untreated (9.3±2.1 vs 5.3±1.1 respectively, p<0.001) FH of group G and T were similar. The high cost of the treatment in group T should be weighted against the results.
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Zadik, Z., Zung, A., Leiberman, E. et al. PREDICTORS OF FINAL HEIGHT (FH) AFTER GROWTH HORMONE (GH) THERAPY IN PERIPUBERTAL SHORT CHILDREN. Pediatr Res 33 (Suppl 5), S54 (1993). https://doi.org/10.1203/00006450-199305001-00305
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DOI: https://doi.org/10.1203/00006450-199305001-00305