Abstract
The AVP response to insulin-induced hypoglycemia was studied in children. They included 36 with non-endocrine short stature (NESS, aged 9.6±2.9y), 6 with isolated GH deficiency (1GHD, 13.2±1.2y), 10 with brain organic disorders affecting one or more anterior pituitary hormones (9 with tumors, 1 with empty sella; 2 accompanying DI; 11.4±2.4y) and 4 with anorexia nervosa (AN, 15.0±3.0y). AVP in plasma was measured at 0, 30, and 60 min in ordinary ITT. Plasma AVP rose significantly in NESS and IGHD. While 2 patients with DI had non-detectable AVP levels, 8 with brain organic diseases lacking clinical DI and 4 with AN had both low basal levels and blunted responses. The increment of AVP was not correlated either with ΔNa, ΔsOsm, ΔBS, bone age, pubertal stage or degree of obesity. These findings suggest that (1)AVP response is clearly present also in children although the secretion mechanism has not been fully understood, and (2) it can be a sensitive tool in evaluating hypothalamic control of AVP especially in patients who do not present DI.
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Yokoya, S., Hachiyo, M. & Ito, R. ARGININE VASOPRESSIN (AVP) RESPONSE TO INSULIN-INDUCED HYPOGLYCEMIA IN CHILDREN. Pediatr Res 33 (Suppl 5), S33 (1993). https://doi.org/10.1203/00006450-199305001-00181
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DOI: https://doi.org/10.1203/00006450-199305001-00181