Growth hormone (GH) pituitary reserve and magnetic resonance imaging (MRI) findings were studied in 22 short prepubertal slow growing children (aged 6-11 yrs; males 14). We assessed GH responses to a combined administration of arginine (0.5g/kg) plus GH-releasing hormone (GHRH, 1μg/kg) (Arg+GHRH test) and mean spontaneous nocturnal GH secretion (MGHC, normal = >3 ng/ml). Subjects were divided into 3 groups, comparable in ages, heights and growth rates: group I, 5 GH deficient children, with reduced GH pituitary reserve (Arg+GHRH GH peaks: <20 ng/ml; mean±SE values=8.4±0.8 ng/ml) and low MGHC (2±0.2 ng/ml); group II, 9 GH deficient patients, with normal GH pituitary reserve ((Arg+GHRH GH peaks= >20 ng/ml; 58.3±7.9 ng/ml) and low MGHC (1.9±0.3 ng/ml); group III, 8 slow growing children, with normal GH pituitary reserve (Arg+GHRH peak: 51.1±13.2 ng/ml) and normal MGHC (5.4±0.8 ng/ml). MRI examination was performed to measure height, width, lenght and volumes of the pituitary gland. Results. All children showed a normal pituitary anatomy without stalk interruption; mean gland measurements were not significantly different between the 3 groups (height: 2.7±0.5, 3.5±0.3, 3.1±0.3 mm in groups I, II, III, respectively; volumes: 111.6 ± 32, 124.5 ± 15 and 126.3 ± 20 mm3, respectively). These data show that in subjects with normal pituitary anatomy and intact stalk the GH pituitary reserve is not correlated with magnetic resonance imaging findings.
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Dammacco, A., Pesce, S., Acquafredda, A. et al. ASSESSMENT OF GROWTH HORMONE PITUITARY RESERVE AND MAGNETIC RESONANCE IMAGING FINDINGS IN SHORT CHILDREN. Pediatr Res 33, S31 (1993). https://doi.org/10.1203/00006450-199305001-00165