Abstract
In previous studies with normal subjects we have demonstrated a straigt relationship between pulsatility and growth hormone (GH) secretion (1). To assess whether this relation is not specific to normal subjects, we have studied comparatively groups of patients in different pathophysiological states, but with the same degree of secreted GH. The patients studied were boys, classified in groups with high or low spontaneous GH secretion (GH-24 h profile). Group 1-high-secretion Ia: 14 prepubertal with low weight for height vs Ib: 21 normal pubertal, Groups II-low-secretion IIa: 11 obese prepubertal vs IIb: 11 prepubertal with GH deficiency and normal weight.
Spontaneous GH secretion was evaluated by 20 minutes sampling (cormed pump). Pooled specimens were formed to measure 24h integrated concentration (IC-GH). The pulses (number and areas) and the area under curve (AUC) in the 24 h profile were estimated with the Pulsar program. Moreover, the pulses were classified as small or large depending on whether their amplitude was ≥ 4ng/ml. GH levels were evaluated by IRMA (Hybritech).
No statistical differences were found between mean values of subgroups, a and b in both groups.
CONCLUSION: Patients with the same amount of secreted GH show very similar secretory pattern despite their pathophysiological situation.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Herrera-Justiniano, E., Diaz, M., de la Cuesta, C. et al. SIMILAR SECRETORY PATTERN IN GROUPS OF PATIENTS WITH THE SAME AMOUNT OF SECRETED GROWTH HORMONE. Pediatr Res 33 (Suppl 5), S29 (1993). https://doi.org/10.1203/00006450-199305001-00158
Issue Date:
DOI: https://doi.org/10.1203/00006450-199305001-00158