Abstract
We wished to determine whether stress in ventilated newborns was reduced by morphine infusions.
Methods: 26 sick neonates requiring ventilation were given a loading dose of Morphine (50 or 150 ug/kg) followed by a constant infusion (10 ug/kg/hr). Plasma catecholamines (HPLC) were measured before, during and after the infusions.
There is a significant reduction (P<0.05) of noradrenaline levels during the infusions. No complications referable to the infusions were noted and with the small numbers, no difference was found between the 2 loading doses.
Conclusions: morphine infusions significantly reduce the neurochemical stress response to ventilation in newborn infants.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McIntosh, N., Cunningham, S., Wright, S. et al. EFFECT OF MORPHINE INFUSIONS ON PLASMA CATECHOLAMINES IN VENTILATED NEONATES. Pediatr Res 32, 632 (1992). https://doi.org/10.1203/00006450-199211000-00167
Issue Date:
DOI: https://doi.org/10.1203/00006450-199211000-00167