Abstract
MAVT has been proposed for the treatment of irreversible hepatic dysfunction secondary to the neonatal short bowel syndrome and total parenteral nutrition. Evolution of the intestinal graft after MAVT In two male, 18 and 10 month old infants was studied by means of nutriment absorption rates and periodical endoscopic and histologic examination. The graft comprised the liver, the stomach, the duodeno-pancreas and the jejunum in one case or the small intestine and a part of the colon in the other case. Immunosuppression Included antilymphocyte-globulins, corticosteroids, azathioprlne and cyclosporin.
In both cases, 2 and 3 months after MAVT, intestinal biopsies revealed irregularly located inflammatory lesions of the mucosa, consisting of a multicellular infiltrate and villous atrophy, whereas previously described, typical aspects of small bowel rejection were not observed. Near-normal nutrient absorption (absorption rate for carbohydrates: 97%) was achieved despite the develoment of these lesions in one infant, who deceased of intractable sepsis on the seventh month. The second patient Is presently treated with high doses of corticosteroids after unsuccessful! OKT3 therapy.
These observations may be consistent with a particular form of acute intestinal rejection, associated with MAVT.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Simeoni, U., Boudjema, K., Geiss, S. et al. EVOLUTION OF THE INTESTINAL GRAFT AFTER MULTIPLE ABDOMINAL VISCERA TRANSPLANTATION (MAVT). Pediatr Res 32, 632 (1992). https://doi.org/10.1203/00006450-199211000-00166
Issue Date:
DOI: https://doi.org/10.1203/00006450-199211000-00166