Abstract
The response of protein turnover to changes in nitrogen (N) intakes was studied in 6 children (8-16 years) on parenteral nutrition (PN). All were on stable nutritional status receiving cyclic home PN for short bowel or CIPO syndrom. Daily PN intakes included 68.7 ±13.0 Kcal/Kg lean body mass (LBM) with 25.4 ±3.6 % lipid (Intralipid 20 %). Non protein energy, water and electrolytes remained unchanged while patients were given for 3 consecutives 7 days periods 0.7, 1.5, 2.5 g of aminoacids (AA) per Kg LBM/day. On day 7 of each period children received a short (4h) constant infusion of L-[1-13C] leucine during IV feeding; leucine turnover (Ra) and oxydation (Ox) were calculated from 13C-plasma ketoisocaproate and expired 13CO2 enrichments. Non oxydative leucine disposal an estimate of protein synthesis (S) and leucine derived from protein breakdown (B) were calculated. Results : μmol/Kg/LBM/hour Anova * p<0,05 ** p<0,011
Increased AA intakes induce a dose dependent rise in leucine Ra and Ox. (S-B) an index of net protein accretion increase with graded N intakes and correlate with N balance which was negative in 2 children at 0.7 gAA/Kg LBM/day. Those results suggest that increasing AA intakes might be beneficial for children on ton? term PN.
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Goulet, O., Robert, J., Rongier, M. et al. RESPONSE OF WHOLE-BODY LEUCINE METABOLISM TO VARIATION IN PARENTERAL AMINO-ACID INTAKES IN CHILDREN ON TARENTERAL NUTRITION. Pediatr Res 32, 627 (1992). https://doi.org/10.1203/00006450-199211000-00132
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DOI: https://doi.org/10.1203/00006450-199211000-00132