Abstract
Short stature is a central feature in Turner's Syndrome. In the last years several treatment schedules have been proposed in order to improve final height. So complete knowledge of the variants of this Syndrome and the expected final height for a specific country is needed. We analyzed the final heights of 86 patients with Turner Syndrome, 32 with a 45X chromosome constitution (X+SD 138.1+4.92 cm) and 52 with a mosaiciam or a structurally abnormal X (136.8±4.73 cm). Forty five patients were longitudinally follow trough their pubertal growth period. Nine girls received treatment with low doses of ethinyl estradiol, 100 ng/Kg/day (group A), 11 started spontaneeus pubertal development and received no treatment (group B) and 26 patients, treated with standard replacement doses of estrogen(17 patients non XD group C and 8 XO group D). In all patients height prediction was calculated by Eayley-Pinnaau method at the onset of spontaneous puberty cr at the beginning of the replacement therapy and the total height gain between this onset and final height was calculated.
In prepubertal girls with Turner Syndrome a slight acceleration of growth velocity under treatment with low doses or a conventional estrogen therapy was seen, but final height was the same in all group. We also noticed that Argentine girls with Turner Syndrome have an ultimate height below the average height reported for European (X 143 cm) or American girls (X 142.6 cm).
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Rudaz, C., Aranda, E., Martínez, A. et al. 19 GROWTH AND FINAL HEIGHT IN PATIENTS WITH TURNER SYNDOROME. Pediatr Res 32, 252 (1992). https://doi.org/10.1203/00006450-199208000-00042
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DOI: https://doi.org/10.1203/00006450-199208000-00042