Abstract
Natural surfactant replacement is associated with marked improvements in oxygenation (PaO2 often >12 kPa) and a 40% reduction in mortality, though survivors may require prolonged periods of intensive care. We studied 66 babies [Mean (sd) birthweight 1013 (240)g, gestational age 27.2 (1.9) wk] who were treated with Curosurf for severe respiratory distress syndrome, to determine if treatment is associated with an increase in the incidence of ROP. Babies were examined by indirect ophthalmoscopy at 6 wk postnatal age and thereafter at 1-2 wk intervals to discharge. Findings were documented according to the International Classification of ROP. Fifty-three (80%) babies survived to discharge; 4 survivors were not examined due to transfer elsewhere. ROP developed in 14 (29%) of the 49 babies examined (8 stage I, 2 stage II, 2 stage II+, 2 stage III) but no baby required cryotherapy. The incidence of ROP in this uncontrolled group is similar to that of non-surfactant treated very low birth weight (VLBW) babies in the UK. We conclude that natural surfactant therapy does not increase the incidence of acute ROP in VLBW babies.
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Tubman, T., Rankin, S., Halliday, H. et al. 175 Impact of surfactant replacement therapy on the incidence of retinopathy of prematurity (ROP). Pediatr Res 30, 657 (1991). https://doi.org/10.1203/00006450-199112000-00205
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DOI: https://doi.org/10.1203/00006450-199112000-00205