Abstract
There is a sufficient amount of data that TNF-alpha, the monokine produced by macrophages after bacterial stimulation might be an important factor responsible for irreversible tissue damage during the septic shock. In an attempt to elucidate the possible function of TNF-alpha in the pathomechanism of sepsis the assesment of TNF-alpha activity in the blood of newborns with bacterial septicaemia was performed. A sample of 21 newborns with sepsis (13 with Staph.epi., 1 with Staph.aur., 7 with G(-) bacteria) was studied. A group of 22 infection-free infants matched by gestational age, birthweight and sex, were used as a controls. TNF-alpha in the blood was determined by ELISA method. For statistic analysis a non-parametric (Wilcoxon) test was used.
Comparisons: A:B(p <.025). A:C(p <.001), B:C(p <.005)
Conclusions: 1. Infants with G(+) and G(-) sepsis reveal significant activity of TNF-alpha in their blood. 2. G(+) bacteria seem to be more potent stimulator of TNF-alpha production in vivo than the G(-) ones.
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Mitkowska, Z., Kowalczyk, D., Pietrzyk, J. et al. 115 TUMOR NECROSIS FACTOR alpha(TNF-alpha) IN NEONATAL SEPTICAEMIA. Pediatr Res 30, 647 (1991). https://doi.org/10.1203/00006450-199112000-00145
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DOI: https://doi.org/10.1203/00006450-199112000-00145