Abstract
Thromboembolic events, which are associated with significant morbidity and mortality, occur in β thalassemia major patients. Eldor et al.(Am.J.Hemat.32:94, 1989)reported findings of increased circulating platelet aggregates and short platelet lifespan, suggesting platelet activation. We studied the expression of the platelet selectin CMP-140 on intact cells from thalassemic patients, as a marker of platelet activation. Blood was collected in glutaraldehyde solution from 10 children and from 10 health adult donors. Platelets were isolated and the expression of GMP-140 was measured by flow-cytometry, using the monoclonal antibody CLB-Thromb./6. The mean of positive cells was 18 ± 6 vs 5 ± 2 (Wilcoxon test:p < 0.01) Our study indicates that in fact platelets are activated in vivo in children affected with thalassemia major.
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Menichelli, A., Cianciulli, P., Gaviano, E. et al. 108 PLATELET ACTIVATION IN THALASSEMIC CHILDREN. Pediatr Res 30, 646 (1991). https://doi.org/10.1203/00006450-199112000-00138
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DOI: https://doi.org/10.1203/00006450-199112000-00138