Abstract
Intravenous lipid emulsions containing polyunsaturated fat are susceptibe to lipid peroxidation, and may trigger cell damage. We Incubated adult (A) or term neonatal (N) erythrocytes with 0.44 % Inlrallpld® (IL) In phosphate-buffered saline for 17 h. Hemolysis was 40.5±2.1% in A and 22.4±1.3% in N (p<0.001). MCV increased by 69.7% in A and 48.5% in N (p<0.001). Glutathione (GSH) decreased in A from 63.6±4.7 to 21.6±4.5 (66.0 %) and in N from 61.1 ±5.9 to 25.7±5.0 mg/dl (57.9%)(changas p<0.001). However, malondialdehyde and conjugated dienes were higher in N (both p<0.001). Desferoxiamine or sodium etidronate inhibited the effects of IL in both A and N. We conclude that despite higher lipid peroxidation in the membrane, the newborn red cell is more resistant to free radical damage than that of the adult.
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Kljuchinikov, S., Pitkäaen, O., Raivio, K. et al. 104 NEWBORN ERYTHROCYTES ARE MORE RESISTENT THAN ADULT TO FREE RADICAL-MEDIATED DAMAGE CAUSED BY LIPID EMULSION. Pediatr Res 30, 645 (1991). https://doi.org/10.1203/00006450-199112000-00134
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DOI: https://doi.org/10.1203/00006450-199112000-00134