Abstract
The tumourigenicity of neoplastic hamster and mouse cell lines and tumour explants was reduced by infection with herpes simplex virus (HSV-1), a thymidine kinaseless mutant of herpes simplex virus (MDK), encephalomyocarditis virus (EMC) and bovine mammillitis virus (BMV). There was an approximate relationship between duration of virus infection in vitro and reduction in the rate of tumour development. The rate of tumour development was also reduced by ‘site inoculation’ of virus (HSV-1) at various time intervals following inoculation of tumourigenic BHK-21 cells indicating that virus was capable of reducing the rate of tumour development in a situation where the neoplastic cells were already transplanted into the susceptible host species. Finally, inoculation of herpesviruses and encephalomyocarditis virus into established subcutaneous tumours in hamsters and mice reduced the rate of tumour growth.
It is suggested that the therapeutic role of wild type, mutant or recombinant viruses merits further exploration towards prevention and treatment of human cancer.
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Skinner, G., Davies, J., Cowan, M. et al. 100 MODIFICATION OF TUMOUR GROWTH BY HERPES SIMPLEX VIRUS AND OTHER VIRUSES. Pediatr Res 30, 644 (1991). https://doi.org/10.1203/00006450-199112000-00130
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DOI: https://doi.org/10.1203/00006450-199112000-00130