Abstract
The role of liver immaturity in the pathogenesis of severe J in G6PD deficient newborns is debated. Plasma levels of CP, a protein synthesized by the liver, could provide an assessment of hepatic immaturity. CP was measured by nephelometry in cord-blood in 4 Groups of newborns either without J (maximum serum bilirubin <8 mg/dl) or with J (max.bilirubin >15 mg/dl) :Group 1),20 full-term without J; Group 2), 20 full-term with J of unknown etiology;Group 3), 12 G6PD deficient without J;Group 4), 12 G6PD deficient with J. Mean CP levels in Groups 2) and 4) were significantly lower than in 1) and 3) (p<0.05). CP was also measured on day 2-3 in 3 Groups of infants: Group 5), 26 full-term without J;Group 6),36 full-term with J;Group 7), 31 G6PD deficient with J.Mean CP levels in Groups 6) and 7) were significantly lower than in 5), (p<0.05). These results, and our previous observations of an elevated α-Fetoprotein level in cord-blood of newborns with J (*), suggest that liver immaturity plays an important role in the genesis of J in both normal and G6PD deficient newborns. They also suggest the possibility of identifying at birth those infants who are at risk of severe J requiring treatment. (*) Ped.Res.22:225, 1987 and 24:268, 1988.
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Balata, A., Corchia, C., Forteleont, G. et al. 98 PLASMA CERULOPLASMIN (CP) LEVELS IN NEWBORN INFANTS WITH SEVER JAUNDICE (J) OF UNKNOWN ETILOGY AND WITH J DUE TO GLUCOSE-6-PHOSPHATE-DEHYDROGENASE (G6PD) DEFICIENCY. Pediatr Res 30, 644 (1991). https://doi.org/10.1203/00006450-199112000-00128
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DOI: https://doi.org/10.1203/00006450-199112000-00128