Abstract
Ventilated VLBW infants usually receive only glucose during the first day of life. These infants are prone to hypo- and hyper glycemia, and it is unknown if this is due to changes in glucose oxidation(Gluox) or non-oxidative disposal (NOD). We studied glucose turnover and oxidation in 7 ventilated VLBW infanta (birthweight 1.25 ± 0.30 kg; gestional age 32 ± 2 weeks; postnatal age 17 ± 5 hrs) by a primed constant infusion of the stable isotope U-13C-glucose. The rate of appearance of glucose (Ra) was measured from the plasma (m+6) enrichment using GC-MS, glucose oxidation was measured as 13CO2 excretion in breath. Results as mean ± 1sd:
Conclusion: 1. Endogenous glucose production was still present in all infanta (2.24±0.84 mg/kg.d) 2. Glucose oxidation was less than glucose intake 3. Non-oxidative disposal accounts for more than 50% of total Rate of appearance of glucose.
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van Goudoever, J., Sulkers, E., Efstathopoulos, T. et al. 83 GLUCOSE OXIDATION ON THE FIRST DAY OF LIFE IN VENTILATED VLBW INFANTS. Pediatr Res 30, 642 (1991). https://doi.org/10.1203/00006450-199112000-00113
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DOI: https://doi.org/10.1203/00006450-199112000-00113