Abstract
An energy intake of 120 kcal/kg.d in preterm infants resulted in a higher fat accretion than in utero. To study if a reduced energy intake would not only reduce fat accretion, but also influence protein(pro) turnover(Q), we measured leucine(leu) kinetics in 4 wk old, orally fed VLBW infants, receiving 3.2 g pro/kg.d. They were fed either 120 -(n = 12, bw= 1.1 ±0.2 kg, ga = 30±2 wkl or 100 kcal/kg.d (n = 12, bw = 1.1 ±0.2 kg, ga = 31±2 wk).13C-Leucine was given orally, 13C-KIC plasma dilution was measured by GC-MS, 13CO2 excretion by IRMS. Results: mean ± 1 sd, Leu kinetics in mmol/kg.hr, Pro kinetics in g/kg.d. C = Catabolism, S = Synthesis, Ox = oxidation. Ret = retention.
Conclusions: 1. Decreasing energy intake from 120 to 100 kcal/kg.d does not increase protein catabolism or alter protein turnover. 2. Protein retention is higher in SGA infants.
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van Goudoever, J., Sulkers, E., Halliday, D. et al. 77 PROTEIN TURNOVER IS NOT INFLUENCED BY DIFFERENT ENERGY INTAKES IN PRETERM INFANTS. Pediatr Res 30, 641 (1991). https://doi.org/10.1203/00006450-199112000-00107
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DOI: https://doi.org/10.1203/00006450-199112000-00107