Abstract
In the neonate, the role of ANP in the regulation of fluid balance is not clear. We assessed the relation of ANP in preterm infants to renal function and PDA on days 2 and 5. P-ANP was measured by RIA; Gl (<30 wk, n=11) and G2 (30-34 wk, n=12). PDA was assessed on day 2. P-ANP was higher in G1 than in G2 (p<0.01) and decreased by day 5 (p<0.02). A negative correlation between P-ANP and GA was found (day 2: r=-0.54, p< 0.01; day 5: r=-0.45, p<0.05). No correlation between P-ANP and CCr or UNP V was found. Infants with PDA had higher P-ANP than infants without PDA in G1 (p<0.02), but not in G2. Preterm infants are able to release huge amounts of ANP postnatally. The high P-ANP concentrations seen postnatally do not directly correlate to the renal regulation of sodium and water balance.
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Ekblad, H., Kero, P., Vuolteenaho, O. et al. 37 ATRIAL NATRIURETIC PEPTIDE (ANP), RENAL FUNCTION, AND PDA IN PRETERM INFANTS. Pediatr Res 30, 634 (1991). https://doi.org/10.1203/00006450-199112000-00067
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DOI: https://doi.org/10.1203/00006450-199112000-00067