Abstract
NIR spectroscopy was used to measure the effect of aminophylline on cerebral blood flow (CBF) and volume (CBV). Mean arterial BP, heart rate, transcutanenus (tc) pO2 and μO2 and intracerebral concentrations of oxyhaemoglobin (oxyHb), deoxyhaemoglobin, and cytochrome aa3 were continuously recorded (Hamamatsu Photonics KK, NIR1000). CBF was estimated using change in oxyHb concentration as a tracer (ret.1). Twenty CBF measurements wore made on 4 preterm infants (birthweight 739-893g. gestation 25 - 28w, age 3-18d) receiving a loading infusion of 6.2 mgs/kg aminophylline. CBF was unchanged in one infant and fell in 3. Median reduction of CBF was 23% (median 3.8 mls/100g/min, range 0 - 9.8). There was no consistent change in CBV. All infants showed a slight fall in tcpCO2 (median 0.2 KPa range 0.14 - 0.7) and a rise in mean BP (median 3mmHg, range 2 - 4). Aminophylline may have effects on CBF independent of CO2 mediated changes.
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McDonnell, M., Ives, N. & Hope, P. 31 THE EFFECT OF AMINOPHYLLINE ON CEREBRAL, HADDYNAMICS ASSESSED BY NEAR INFRA-RED (NIR) SPECTROSCOPY. Pediatr Res 30, 633 (1991). https://doi.org/10.1203/00006450-199112000-00061
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DOI: https://doi.org/10.1203/00006450-199112000-00061