Abstract
A previous study suggested that changes in cerebral blood volume in response to carbon dioxide (CO2) are greater in term than in preterm infants (Wyatt: Ped Res 1990;28;290).
The AIM of this study was to investigate the influence of postnatal age and sleep state on this CO2-response in healthy full-term neonates.
METHODS: 21 infants were studied on day 1 and 4. A change in tcPCO2 was monitored continously with a sensor heated to 44 C (Kapnomonitor Hellige) and cerebral blood volume was assessed by near infrared spectroscopy with emitter and receiver placed 4.5cm to 7cm apart over the right temporal region (NIR 1000 Hamamutsu). Sleep state was observed clinically.
There was no significant difference between day 1 and day 4, nor between active and quiet sleep.
CONCLUSION: Cerebral blood volume in response to CO2 varies widely in normal term neonates. As postnatal age and sleep state do not explain this variation, further studies are needed to clarify the nature of this wide range.
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Bucher, HU., Diener, U. & Duc, G. 29 CARBON DIOXIDE INDUCED CHANGES IN CEREBRAL BLOOD VOLUME IN THE NORMAL TERM NEONATE. Pediatr Res 30, 633 (1991). https://doi.org/10.1203/00006450-199112000-00059
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DOI: https://doi.org/10.1203/00006450-199112000-00059