Abstract
The effects of hypoxemia (HO, 10% O2) and hypovolemia (HV, bleeding 20–30%) alone, or both insults combined, on retinal (RBF) and choroidal blood flow (ChBF) wete studied in 23 newborn piglets with the microsphere method. Surgery and experiments were performed under general anesthesia with 70% N2O. The piglets were ventilated paralyzed with pancuronium. RBF and ChBF were measured at baseline (Bl), during HO or at baseline 2 (Bl2), 20 min after HO (20′) or after HV, and 30 (30′) and 60 min (60′) after HO. Results were (ml/min/100g):
RBF was significantly increased during HO, but was not affected by HV. ChBF was also increased during HO, but much less than RBF. HV significantly reduced ChBF. These different responses within the ocular vascular bed miqht have clinical significance.
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Odden, JP., Bratlid, D., Hall, C. et al. 19 THE EFFECT OF HYPOXEMIA AND HYPOVOLEMIA ON RETINAL AND CHOROIDAL BLOOD FLOW IN THE NEWBORN PICLET. Pediatr Res 30, 631 (1991). https://doi.org/10.1203/00006450-199112000-00049
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DOI: https://doi.org/10.1203/00006450-199112000-00049