Abstract
ABSTRACT: Intralipid, derived from soybean oil and containing a high percentage of n-6 family polyunsaturated fatty acids (PUFA) and also linolenic acid, an n-3 family PUFA, is commonly the first fat source provided to very low birth weight premature infants. Following up on our previous reports that newborn rats born to dams fed high-PUFA diets demonstrate superior tolerance to hyperoxia, we examined whether the high-PUFA fat source Intralipid might also protect against oxygen toxicity. Adult female rats were fed either regular Rat Chow or fat-free diet containing 20%-Intralipid as the fat source for 3 wk before and then throughout pregnancy and lactation. One- and 5-d-old offspring of Intralipid diet-fed dams demonstrated significant increases in lung lipid n-6 family PUFA plus elevated linolenic acid compared with regular diet-fed offspring. These characteristic fatty acid patterns, apparent in total lung lipids, were even more pronounced in the triglyceride fraction compared with the phospholipid fraction. Associated with these fatty acid changes were significantly improved hyperoxic survival rates (89 out of 95 = 94% survival after 7 d of >95% O2 exposure) in Intralipid offspring (versus 89 out of 106 = 84%, p < 0.05 in regular diet offspring) and evidence of superior clinical/pathologic status. No differences in pulmonary antioxidant enzyme or surfactant system development, response of antioxidant enzymes to hyperoxic exposure, or lung prostaglandin E2, 6-keto PGF2-α or leukotrienes C4-F4 were present. These findings continue to support the hypothesis that increasing lung PUFA content may provide increased O2 free radical scavenging capacity, thus protecting against hyperoxic lung damage. The results also suggest a role for Intralipid administration in protecting the lungs of high oxygen-exposed very low birth weight premature infants.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sosenko, I., Innis, S. & Frank, L. Intralipid Increases Lung Polyunsaturated Fatty Acids and Protects Newborn Rats from Oxygen Toxicity. Pediatr Res 30, 413–417 (1991). https://doi.org/10.1203/00006450-199111000-00004
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-199111000-00004
This article is cited by
-
C22-bronchial and T7-alveolar epithelial cell lines of the immortomouse are excellent murine cell culture model systems to study pulmonary peroxisome biology and metabolism
Histochemistry and Cell Biology (2016)
-
Developmental changes in polyunsaturated fetal plasma phospholipids and feto-maternal plasma phospholipid ratios and their association with bronchopulmonary dysplasia
European Journal of Nutrition (2016)
-
Peroxisomes in dental tissues of the mouse
Histochemistry and Cell Biology (2013)
-
Peroxisomes in mouse and human lung: their involvement in pulmonary lipid metabolism
Histochemistry and Cell Biology (2008)