Abstract
We analized prospectively 15 boys with cryptorchism: 6 at right side, 6 at left and 3 bilateral, treated with hCG(750 U/m2/dose; 2x/wk)+hMG (100 U/m2/dose; 2x/wk) during 6 weeks. Mean follow-up was 8,8 months. We strictly excluded the retractile and the nonpalpable testes. In all cases, sexual cromatin was negative and the plasma testosterone peak was normal. Ultrasonographic studies had difficulties to determine the exact testicular position. Side effects; Androgenic signs (15 cases) darker urine (9) increased appetite (8) diuresis increase (6) facial swelling and restless sleep (5)' Tile only side effect that persisted was penile enlargement (meanĀ°1.25cm; range 0.4-2.2 cm). Testicular descent: unilateral cases (12): partial descent in 2; bilateral cases (3): descent in 2 cases. Testicular retraction: Occured in all but one testis. Light microscopy: decrease of tubular volume and spermatogonia number.
CONCLUSION: This dosage of hCG+hMG was sufficient to elicit androgenic effects in all boys, and the testosterone peak was in the normal range. With careful exclusion of retractile testes, testicular descent was obtained in 4 boys (26%), however in all but one, retraction occured on the average 8 weeks follow-up. Preliminary data on testicular histology, suggest that testicular anomalies arc present already in the second year of life.
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Longui, C., Arnhold, I., Mendonca, B. et al. CRYPTORCHISM IN BOYS UNDER 4 YEARS: TREATMENT WITH hCG + hMG. Pediatr Res 28, 422 (1990). https://doi.org/10.1203/00006450-199010000-00043
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DOI: https://doi.org/10.1203/00006450-199010000-00043