Abstract
After 1987 10 RSOLT and one OLT have been performed in 10 pts at a mean age of 4.3y (range 0.6-14.2); in 3 pts over the ABO barrier. The diagnoses were: biliary atresia (4 pts), tyrosinemia (3 pts), alpha-1-antitrypsin deficiency, liver adenoma and hepatoblastoma. Triple immunosupression (MP, Az and CyA) with constant i.v. CyA infusion (B-CyA-spes=500-600 ug/L) for 2 w and MP+CyA after 2 mo. Two arterial thromboses were seen; one led to re-OLT and the other cleared with local i.v. streptokinase infusion for 2d. Five pts had one rejection 5-21d (mean 12) after OLT and responded to 3 mg/kg/d p.o. MP for 5d. There was no rejection in the 3 pts were the ABO barrier was crossed. CMV viremia with clinical symptoms was seen in 5 pts and treated with gancyclovir.
After a mean follow-up time of 0.8y (range 0.3-2.5y) all pts are at home with a functioning graft. Psychomotor development and growth (catch-up growth after 6 mo) are normal, mean SGPT is 30 U/L, gamma GTP 26 U/L and creatinine 49 umol/L.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Holmberg, C., Jalanko, H., Leijala, M. et al. 105 REDUCED SIZE ORTHOPTIC LIVER TRANSPLANTATION (RSOLT) IN FINNISH CHILDREN. Pediatr Res 28, 294 (1990). https://doi.org/10.1203/00006450-199009000-00129
Issue Date:
DOI: https://doi.org/10.1203/00006450-199009000-00129