Abstract
Adults with ileal disease or resection have biliary cholesterol supersaturation and are therefore prone to cholesterol cholelithiasis. Our previous studies have shown that bile from children witli ileal resection/disease (IR/D) was not supersaturated with cholesterol (Gastroenterol 1982;82:1295). The present study was designed to test the hypothesis that infants with IR/D will develop biliary cholesterol supersaturation after puberty presumably because of the influence of sex hormones in biliary secretion. Five sexually mature subjects (3M, 2F, age 16-19 yr) who had been previously investigated in childhood (ages 4-9 yrs) were studied. Ultrasound examination of the gallbladder performed using real-time sonography revealed gallstones on one subject. Duodenal bile samples, obtained after an overnight fast, were examined for bile acids (BA), phospholipid (PL) and cholesterol (XOL), and the molar fraction (M%) and lithogenic index (LI) calculated. Comparisons are shown between subjects prior to puberty (C), post puberty (PP) and 20 young adult controls [x±SEM, *p<.001 or +p <.005 vs. Ileal disease (PP)]:
Conculsions: Children with ileal resection/dysfunction are not at risk for cholesterol gallstone Formation during childhood; however, biliary cholesterol supersaturation after puberty predispose them to cholesterol cholelithiasis.
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Heubi, J., O'Connell, N. & Setchell, K. ILEAL RESECTION/DYSFUNCTION PREDISPOSES TO LITHOGENIC BILE AFTER PUBERTY. Pediatr Res 27, 542 (1990). https://doi.org/10.1203/00006450-199005000-00102
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DOI: https://doi.org/10.1203/00006450-199005000-00102