Abstract
We studied the effect of Hypoxanthine (Hx) and Xanthine Oxidase (XOD) on release of [3H]-DA from rat striatal synaptosomes. Synaptosomes were isolated through centrifugation, labelled with [3H]-DA, recentrifuged and the pellets P2 were used. Hx and XOD, alone or with scavengers, Catalase (CAT) and Superoxide Dismutase (SOD), were added before incubation of the P2. Spontaneous and K+-evoked (50 mM) release were measured using a filtration method:
These results suggest that oxygen radicals, especially H2O2, may alter neurotransmitter functions. This could represent a neurochemical basis of behavioral changes observed in newborns during and after a hypoxic episode.
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Poulsen, J., Lun, A., Scheuch, C. et al. OXYGEN RADICALS STIMULATE DOPAMINE (DA) RELEASE FROM RAT STRIATAL SYNAPTOSOMES. Pediatr Res 26, 518 (1989). https://doi.org/10.1203/00006450-198911000-00115
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DOI: https://doi.org/10.1203/00006450-198911000-00115